Harry B Rossiter, PhD

Harry B Rossiter, PhD

Investigator, LA BioMed
Associate Professor of Respiratory & Critical Care Physiology & Medicine, David Geffen School of Medicine at UCLA
Director of Research Training, Division of Respiratory Critical Care Physiology and Medicine, Harbor-UCLA Medical Center
Director of the UCLA-CTSI High Resolution Tissue Respirometry Core at LA BioMed

Contact

The integrative biology of exercise

Research Description

Dr. Rossiter's research mission is to improve the lives of patients in whom exercise intolerance is a major symptom. For this he uses a range of in situ, in vivo, and computational methods to study physiological responses to exercise with special reference to chronic pulmonary diseases and pulmonary rehabilitation. His lab conducts respiratory research and clinical trials focusing on the following areas:

1) Control of oxidative phosphorylation, mitochondrial function and their contribution to metabolic health and biological aging.
2) The mechanisms of exercise intolerance, muscle fatigue and symptom limitation in health and chronic disease.
Research Interests

Education

  • BS, 1995, University of Birmingham, UK
  • MS, 1996, King’s College, University of London, UK
  • PhD, 2000, St. George’s Hospital, University of London, UK

Recent and/or Significant Publications

  1. Adami A, Hobbs BD, McDonald ML, Casaburi R, Rossiter HB; (2018). Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD. Physiol Genomics. 2018 May 25. doi: 10.1152/physiolgenomics.00140.2017. [Epub ahead of print]
  2. Adami A, Rossiter HB. (2018). Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy. J Appl Physiol. 2018 Jan 1;124(1):245-248.
  3. Rana, A., Oliveira, M. P., Khamoui, A. V., Aparicio, R., Rera, M., Rossiter, H. B., & Walker, D. W. (2017). Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nature Communications, 8(1), 448.
  4. Bhatt S. P., Soler X., Wang X., Murray S., Anzueto A. R., Beaty T. H., Boriek A. M., Casaburi R., Criner G. J., Diaz A. A., Dransfield M.T., Curran-Everett D., Galbán C. J., Hoffman E. A., Hogg J. C., Kazerooni E. A., Kim V., Kinney G. L., Lagstein A., Lynch D. A., Make B. J., Martinez F. J., Ramsdell J. W., Reddy R., Ross B. D., Rossiter H. B. , Steiner R. M., Strand M. J., van Beek E. J., Wan E. S., Washko G. R., Wells J. M., Wendt C. H., Wise R. A., Silverman E. K., Crapo J. D., Bowler R. P., Han M. K.; COPD Gene Investigators. (2016). Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 194(2):178-84.
  5. Puente-Maestu L., Palange P., Casaburi R., Laveneziana P., Maltais F., Neder J. A., O'Donnell D. E., Onorati P., Porszasz J., Rabinovich R., Rossiter H. B., Singh S., Troosters T., Ward S. (2016). Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J 47(2):429-60.
  6. Roman MA, Rossiter HB, Casaburi R (2016). Exercise, ageing and the lung. Eur Respir J 48(5):1471-1486.
  7. Porszasz J, Blonshine S, Cao R, Paden HA, Casaburi R, Rossiter HB. (2016) Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials. BMC Pulm Med. 16:13. doi: 10.1186/s12890-016-0174-8.
  8. Cannon, D. T., Coelho, A. C., Cao, R., Cheng, A., Porszasz, J., Casaburi, R., & Rossiter, H. B. (2016). Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD. Journal of Applied Physiology, 121(6), 1365-1373.
  9. Korzeniewski, B., & Rossiter, H. B. (2015). Each‐step activation of oxidative phosphorylation is necessary to explain muscle metabolic kinetic responses to exercise and recovery in humans. The Journal of physiology, 593(24), 5255-5268.
  10. Grassi B, Rossiter HB, Zoladz JA. (2015). Skeletal muscle fatigue and decreased efficiency: two sides of the same coin? Exerc Sport Sci Rev 43(2):75-83.