Alan J Waring, PhD

Alan J Waring, PhD

Professor of Medicine, David Geffen School of Medicine at UCLA

Contact

Protein Engineering

Research Description

The current research focus of Dr. Waring's lab is the study of membrane protein-lipid interactions involved in antimicrobial host defense, pulmonary surfactant activity, and the fusion of enveloped viruses. These studies aim to provide a solid foundation for molecular therapies in diseases such as the respiratory distress syndrome, as well as bacterial, fungal and viral infections.
Theme Groups
Research Interests

Education

  • PhD, 1974, University of California, Los Angeles

Recent and/or Significant Publications

  1. Chaili, S., Cheung, A.L., Bayer, A.S., Xiong, Y.Q., Waring, A.J., Memmi, G., Donegan, N., Yang, S.J., Yeaman, M.R. "The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action", Infect Immun. 2015 Nov 23. pii: IAI.01030-15. [Epub ahead of print] PMID: 26597988
  2. Chakraborty, A., Hui, E., Waring, A., and Dhar, P. “Effect of Synthetic Protein, Mini-B, and Cholesterol on A Model Lung Surfactant Mixture at the Air-Water Interface”, BBA Biomembranes January 5, (2016) pii: S0005-2736(16)00009-2. doi: 10.1016/j.bbamem.2016.01.008. [Epub ahead of print] PMID: 26775740
  3. Micewicz, E.D., Sharma, S., Waring, A.J., Luong, H.T., McBride, W.H., and Ruchala, P. "Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation", International Journal of Peptide Research and Therapeutics Mar 1;22(1):67-81 (2016). PMID: 26957954
  4. Waring, A.J., Gupta, M., Gordon, L.M., Fujii, G., and Walther, F.J. “Stability of an Amphipathic Helix-Hairpin Surfactant Peptide in Liposomes.”, Biochim Biophys Acta. 2016 Sep 21 pii: S0005-2736(16)30312-1. doi: 10.1016/j.bbamem.2016.09.014. [Epub ahead of print] PMID: 27664499
  5. Henderson, J.M., Waring, A.J., Separovic, F., and Lee, K.Y.C. “Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction”, Biophys J. (2016) Volume 111, Issue 10, p2176–2189, 15 November 2016http://dx.doi.org/10.1016/j.bpj.2016.10.003 PMID: 27851941