Sharon G Adler, MD

Sharon G Adler, MD

Professor of Medicine, David Geffen School of Medicine at UCLA
Chief, Division of Nephrology and Hypertension at Harbor-UCLA Medical Center
Program Director, Nephrology Fellowship Training Program at Harbor-UCLA Medical Center

Contact

Nephropathy due to glomerular disease and diabetes; Mechanisms of peritoneal injury in peritoneal dialysis

Research Description

Dr. Adler's experimental and clinical research focuses on all aspects of diabetic kidney disease and glomerulonephritis. She recently discovered molecules in the urine that facilitate the identification of kidney disease early on; this discovery is expected to open up new avenues for the treatment of kidney disease and for the preservation of the peritoneal membrane. She is a member of two NIH-sponsored consortia to understand the pathogenesis of glomerular diseases in order to find new treatments based on a more sophisticated understanding of pathogenesis.
Theme Groups

Education

  • BA, 1972, Barnard College, New York
  • MD, 1976, State University of New York (SUNY) Downstate, Medical Center College of Medicine

Recent and/or Significant Publications

  1. Tiane Dai, Wang Y, Nayak A, Nast CC, Quang L, LaPage J, Andalibi A, and Adler SG: Janus Kinase Signaling Activation in the Mediation of Peritoneal Inflammation and Injury in vitro and in vivo in Response to Peritoneal Dialysate. Kidney International (9 July 2014) doi:10.1038/ki.2014.209
  2. Shah AP, Shen JI, Wang Y, Tong L, Pak Y, Andalibi A, LaPage JA, Adler SG: Effects of Minocycline on Urine Albumin, Interleukin-6, and Osteoprotegerin in Patients with Diabetic Nephropathy: A Randomized Controlled Pilot Trial. PLoS One. 2016 Mar 28;11(3):e0152357. doi: 10.1371/journal.pone.0152357
  3. Tong L and Adler SG: How I treat diabetic kidney disease. CJASN: 2017 Oct 18. pii: CJN.04650417. doi: 10.2215/CJN.04650417.
  4. Shah A, Miller CJ, Nast CC, Adams MD, Truitt B, Tayek JA Tong L, Mehtani P, Monteon F, Sedor JR, Clinkenbeard EL, White K, Mehrotra R, LaPage J, Dickson P, Adler SG, Iyengar SK: Severe Vascular Calcification and Tumoral Calcinosis in a Family with Hyperphosphatemia: An FGF23 Mutation Identified by Exome Sequencing. Nephrol. Dial. Transplant. (2014) doi: 10.1093/ndt/gfu324