Fawzia Bardag-Gorce, Ph.D.

Fawzia Bardag-Gorce, PhD

Associate Researcher, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA

Contact

Corneal Epithelium Regeneration

Research Description

Dr. Fawzia Bardag-Gorce research focus is the field of eye research. Her goal is to regenerate the ocular surface of patients suffering from a defect in corneal epithelium renewal. The technology consists of using the patient own cells to treat specific organ failure. Dr. Bardag-Gorce has directed preclinical studies that demonstrated the efficacy of a rabbit Cultured Autologous Oral Mucosal Epithelial Cell Sheet (CAOMECS) to reconstruct the ocular surface. The following efforts focused on demonstrating CAOMECS safety as a treatment for the ocular surface. Bardag-Gorce's team is currently preparing the transition to clinical development to bring CAOMECS to the bedside. Building on her experience and expertise on the ubiquitin-proteasome pathway, Dr. Bardag-Gorce is also focusing on modulating the activity of the ubiquitin proteasome pathway in human corneal epithelial cells as it is a very promising treatment to further enhance corneal transparency after injury or cornea transplantation.

Education

  • MS, 1994, Blaise Pascal University, France
  • PhD, 1999; Blaise Pascal University, France

Recent and/or Significant Publications

  1. Fawzia Bardag-Gorce, et al. Proteasomes in corneal epithelial cells and cultured autologous oral mucosal epithelial cell sheet (CAOMECS) graft used for the ocular surface regeneration. The Ocular Surface. 2017 Oct;15(4):749-758. doi: 10.1016/j.jtos.2017.05.010. Epub 2017 May 18. PMID: 28528957
  2. Fawzia Bardag-Gorce, et al. The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem Deficiency. J Ophthalmol. 2016:4805986. Epub 2016 Sep 29. PMID: 27777792 http://www.hindawi.com/journals/joph/2016/4805986/
  3. Joan Oliva, Fawzia Bardag-Gorce, Andrew Wood, Sota H, Yutaka Niihara. Direct labeling of 19F-perfluorocarbon onto engineered multilayered cell sheet for MRI-based non-invasive cell tracking. Tissue Engineering and Regenerative Medicine. October 2015, Volume 12, Issue 5, pp 371-378. http://link.springer.com/article/10.1007/s13770-014-0092-x
  4. Fawzia Bardag-Gorce, et al. Carrier-free cultured autologous oral mucosa epithelial cell sheet (CAOMECS) for corneal epithelium reconstruction: A histological study. The Ocular Surface. 13(2), 150–163. 2015. DOI: 10.1016/j.jtos.2014.12.003. PMID: 25881998
  5. Fawzia Bardag-Gorce, et al. Microarray analysis of oral mucosal epithelial cell sheet. Tissue Engineering and Regenerative Medicine. 2013;10(6):362-370.
  6. Bousquet-Dubouch M-P, Burlet-Schiltz O, Monsarrat B, French SW, Bardag-Gorce F. Chronic ethanol feeding alters proteasome interacting proteins. Proteomics 2009; 9(13):3609-22. PMCID: PMC2842527.
  7. Bardag-Gorce F, Oliva J, Li J, French BA, French SW. SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Exp Mol Pathol. 2010; 88(3):353-62. PMCID: PMC3315394
  8. Bardag-Gorce F, Oliva J, Lin A, Li J, French BA, French SW. Proteasome inhibitor up regulates liver anti-oxidative enzymes in rat model of alcoholic liver disease. Exp Mol Pathol. 2011; 90(1):123-30. PMCID: PMC3025748
  9. Oliva, J, French SW, Li J, Bardag-Gorce F. Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis. Exp Mol Pathol. 2012; 93(1):26-34. PMCID: PMC4197193.
  10. Bardag-Gorce F. Proteasome inhibitor treatment in alcoholic liver disease. World J Gastroenterol. 2011 May 28;17(20):2558-62. doi: 10.3748/wjg.v17.i20.2558.