Yan Q Xiong, MD, PhD
Professor of Research, Infectious Diseases, Geffen School of Medicine at UCLA
Bacterial pathogenesis and antimicrobial resistance in endovascular infections
Research DescriptionDr. Xiong is an expert in bacterial pathogenesis, antibiotic resistance and animal models of infection, especially in endovascular infections. Her lab focuses on understanding the roles of Staphylococcus aureus key virulence factors (global regulons and structural genes) which contribute to the ability of this pathogen to cause persistent human infections. Her long-term goal is to develop novel antimicrobial strategies for the prevention and therapy of serious infections caused by virulent microbes, including S. aureus.
- MD, 1985, Tongji Medical School, Wuhan, China
- PhD, 1996, University of Nantes, School of Medicine, Nantes, France
Recent and/or Significant Publications
- Abdelhady, W., L. Chen, A.S. Bayer, K. Seidl, M.R. Yeaman, B.N. Kreiswirth and Y.Q. Xiong. Early agr activation correlates with vancomycin treatment failure in multi-clonotype MRSA endovascular infections. J Antimicrob Chemother. 2015 May;70(5):1443-52. PMID: 25564565.
- Abdelhady, W., A.S. Bayer, K. Seidl, D.E. Moormeier, K.W. Bayles, A. Cheung, M.R. Yeaman and Y.Q. Xiong. Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 2014 Apr;209(8):1231-40.
- Abdelhady, W., A.S. Bayer, K. Seidl, C.C. Nast, M.R. Kiedrowski, A.R. Horswill, M.R. Yeaman, Y.Q. Xiong. Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Mar;57(3):1447-54.
- Xiong, Y.Q., W. Abdel Hady, A.S. Bayer, L. Chen, B.N. Kreiswirth, S.J. Yang. Telavancin in the therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA). Antimicrob. Agents Chemother. 2012 Nov;56(11):5528-33.