Yan He Lue, MD
Research Professor, David Geffen School of Medicine at UCLA
Genetic and hormonal regulation of spermatogenesis
Research DescriptionDr. Lue's major research focus has been the genetic and hormonal regulation of spermatogenesis, and testicular stem cell biology. He has demonstrated that testicular hyperthermia enhances the suppression of spermatogenesis induced by testosterone implants in both rats and monkeys. He has characterized the XXY mouse model for investigating the most common sex chromosome aneuploidy in men–Klinefelter’s syndrome. He has been studying the cellular and molecular mechanisms of gonadal and neurobehavioral defects in XXY mice and the effects of the microenvironment on stem cell plasticity in testes and spermatogonial stem cell biology.
- MD, 1993, Shandong University School of Medicine, P.R.China
Recent and/or Significant Publications
- Lue YH, Wang C, Liu PY, Erkilla K, Swerdloff RS. Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model. Pediatr Endocrinol Rev. 2010 Dec;8 Suppl 1:140-4. Review.
- Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010 Jan;151(1):350-7. Epub 2009 Dec 1.
- Ilani N, Armanious N, Lue YH, Swerdloff RS, Baravarian S, Adler A, Tsang C, Jia Y, Cui YG, Wang XH, Zhou ZM, Sha JH, Wang C. Integrity of the blood-testis barrier in healthy men after suppression of spermatogenesis with testosterone and levonorgestrel. Hum Reprod. 2012 Sep 27.