Virender K Rehan, MD
Professor of Pediatrics, David Geffen School of Medicine at UCLA
Chief, Division of Neonatology, Harbor-UCLA Medical Center
Director, Neonatal Intensive Care Unit, Harbor-UCLA Medical Center
Director, Neonatal-Perinatal Fellowship Training Program, Harbor-UCLA Medical Center
Feto-neonatal lung maturity, injury-repair, and transgenerational transmission of acquired traits
Research DescriptionDr. Rehan’s research interests include neonatal lung maturity and injury-repair, with a special emphasis on lung injury repair following perinatal exposure to insults such as hyperoxia, infection, and nicotine. The studies in his lab have provide novel insights into the pathogenesis of Bronchopulmonary Dysplasia (BPD), Childhood Asthma, and Chronic Lung Disease and have lead to the creation of innovative strategies to prevent/treat these conditions. Additionally, Dr. Rehan examines the relationship between Vitamin D consumption over the duration of the perinatal period and its possible impact on childhood asthma. He also studies the potentially serious impact of perinatal exposure to 1st-, 2nd-, and 3rd-hand smoke (the newly formed toxins from tobacco smoke that remain on furniture, in cars, on clothing and other surfaces) on the lung development of not only the exposed offspring, but also on the lung development of the progeny of many subsequent generations that follow after the initial exposure. These studies have vastly expanded our current understanding of the impact of perinatal smoke exposure on the epidemiology of chronic lung disease worldwide.
In 2005, and using as a foundation his years of laboratory work, Dr. Rehan co-founded LA BioMed’s Linc Pharmaceuticals, a company dedicated to developing anti-fibrotic technologies. He currently serves as the organization’s medical affairs adviser.
- MD, 1977, University College of Medical Sciences, Delhi, India
Recent and/or Significant Publications
- Liu J, Sakurai R, Rehan VK. PPAR-γ agonist rosiglitazone reverses perinatal nicotine exposure-induced asthma in rat offspring. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L788-96.
- Morales E, Sakurai R, Husain S, Paek D, Gong M, Ibe B, Li Y, Husain M, Torday JS, Rehan VK. Nebulized PPARγ agonists: a novel approach to augment neonatal lung maturation and injury repair in rats. Pediatr Res. 2014 May;75(5):631-40.
- Yurt M, Liu J, Sakurai R, Gong M, Husain SM, Siddiqui MA, Husain M, Villarreal P, Akcay F, Torday JS, Rehan VK. Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L859-67.
- Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, Akbari O, Torday JS. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med. 2012 Oct 30;10:129.