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Therapeutics

LAB0058: Exogenous Surfactant Protein B Mimic
US Patent No. 7,538,090 issued on

A composition including a C terminal region having residues corresponding to a peptide identified by PDB ID: 1RG3; an N terminal region having residues corresponding to a peptide identified by PDB ID: 1RG4; and a disulfide linkage between the residues near the C terminal region and the N terminal region.

Neonatology Pediatrics Pulmonary
LAB0001: Methods for Treating Refractory Infections in Neutropenic Individuals
US Patent No. 8,790,662 issued on

The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by bacteria, fungi, protozoa, and viruses. The methods of the invention represent a practical, rapid cell-based immunotherapy for refractory infections comprising compositions of activated, irradiated HL-60 cells.

Infectious Diseases
LAB0072: Modulation of Myofiber Repair by Anti-Myostatin Strategies and/or PPAR Gamma Ligands, Alone or in Combination with Stem Cells, for the Therapy of Critical Limb Ischemia and Other Ischemic Processes Affecting the Skeletal Muscle
PCT No. PCT/US2013/074467 filed on

Treating or inhibiting an ischemic condition affecting the skeletal muscle comprising administering an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (GDF-8) according to a regimen to treat or inhibit the ischemic condition. Treating or inhibiting an ischemic condition affecting the skeletal muscle including administering an effective amount of a thiazolidenedione or other PPAR gamma agonist at a dosage that do not exert glycemic control or induce overweight.

Internal Medicine
LAB0003: Peptides and Methods for Inducing Cell Death
US Patent No. 8,492,333 issued on

The invention provide isolated peptides, protides and conjugates having novel peptide sequences which are able to induce antimicrobial, anti-cancer, anti-inflammatory, anti-proliferative or programmed cell death activity. The invention also provides a method of inducing programmed cell death in a cell by contacting the cell with an isolated peptide, protide or conjugate described herein. In some aspects, the method can be used in the diagnosis, prevention, or treatment of a disease, such as an infection, cancer, autoimmune disease, or inflammatory disease.

Infectious Diseases
LAB0007: Compositions and Methods for the Treatment of Mucormycosis and Other Fungal Diseases
PCT No. PCT/US2007/016065 filed on

The invention provides a composition including at least one iron chelating compound and at least one antifungal agent. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The invention also provides a method of treating or preventing a fungal condition.

Infectious Diseases
LAB0008: Vaccine Compositions and Methods for Treatment of Mucormycosis and Other Fungal Diseases
US Patent No. 8,444,985 issued on

The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.

Infectious Diseases
LAB0009: Antimicrobial Kinocidin Compositions and Methods of Use
PCT No. PCT/US2007/014499 filed on

The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an α-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a γKC core and that can be a CXC, CC, or C class chemokine.

Infectious Diseases
LAB0011: Antimicrobial Peptides and Derived Metapeptides
PCT No. PCT/US1999/003350 filed on

This invention relates generally to antimicrobial agents, and more specifically pertains to peptides useful as antimicrobial agents for the prevention and treatment of infections caused by organisms, such as bacteria and fungi, many of which are resistant to conventional antibiotics

Infectious Diseases
LAB0061: A Method for Modifying Myostatin Expression
US Patent No. 8,426,374 issued on

A method of inhibiting myostatin expression or activity to increase muscle mass. Methods for locally inhibiting myostatin expression or activity to reduce fibrosis are provided. The method introduces a nucleotide sequence into a vector wherein the nucleotide sequence is expressed as a shRNA having a property to inhibit myostatin expression. The vector including the sequence may be delivered to a mammalian tissue. An electrical pulse may be applied across a point of delivery.

Skeletal Muscle
LAB0016: Immunotherapy and Diagnosis of Mucormycosis Using CotH
US Patent No. 9,279,002 issued on

The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.

Infectious Diseases
LAB0039: Targeting Pulmonary Epithelium Using ADRP
US Patent No. 8,066,971 issued on

This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The compositions comprise an adipocyte differentiation-related protein (ADRP) attached to an effector thereby forming a chimeric moiety. The chimeric moiety is preferentially delivered to epithelial cells.

Neonatology Pediatrics Pulmonary
LAB0014: Multifunctional Context-Activated Protides and Methods of Use
US Patent No. 8,592,375 issued on

This invention is directed to multifunctional, context-activated protides that have two or more effectors with individually distinct biological functions and one or more corresponding activator sites that can each initiate or amplify the biological function of one or more effectors upon context-activation. The context-activated protides of the invention are useful in the diagnosis, prophylaxis, and therapy of a broad range of pathological conditions.

Infectious Diseases
LAB0129: Intensification of Collagen Breakdown in Tissue Fibrosis by a Combination of Metalloproteinases or Collagenases and AGE Cross-link Breakers
Provisional Application No. 62/289,536 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Urology
LAB0164: Structurally Novel Phenytoin Derivatives with Enhanced Binding to Neuronal Voltage Gated Sodium Channels
Provisional Application No. 62/298,322 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

LAB0163: Aerosol Delivery of a PPARγ Agonist in Synthetic Lung Surfactant to Prevent Neonatal Lung Injury
Provisional Application No. 62/304,845 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Neonatology
LAB0135: Manipulation of Endothelial Yap-Hippo Signaling to Modulate Pulmonary Angiogenesis and Lung Growth and Development
Provisional Application No. 62/325,598 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Pulmonary
LAB0064: Respiratory Distress Syndrome Therapy with Peptide Analogs of Human SP-B
US Patent No. 6,660,833 issued on

A therapeutic pharmaceutical composition for the treatment of respiratory disease is disclosed, including particularly Respiratory Distress Syndrome (RDS). The composition is comprised of a synthetic dimer of an N-terminal fragment of Surfactant Protein B (SP-B) that advantageously mimics the functional activity of native human Surfactant Protein B, and to therapeutic methods of administration of such pharmaceutical compositions.

Neonatology
LAB0094: Induction of Antigen Specific Immunologic Tolerance
US Patent No. 7,883,707 issued on
US Patent No. 7,485,314 issued on

Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. The methods optionally include a preceding conditioning period, where immunosuppressive agents are administered in the absence of the toleragen. After the tolerizing regimen, the host is withdrawn from the suppressive agents, but is able to maintain specific immune tolerance to the immunogenic epitopes present on the toleragen.

LAB0132: Novel SP-B & SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof
PCT No. PCT/US2013/025532 filed on

The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed.

Neonatology
LAB0155: Recombinant Human N-acetylglucosamine-6-sulfatase for Sanfilippo D Syndrome
Provisional Application No. 62/238,024 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

LAB0158: Discovery of Novel Mucormycosis Pathogenesis Mechanism Mediated by Ricin-like Toxin with a Promising Diagnostic and Immunotherapeutic Strategies
Provisional Application No. 62/260,054 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Infectious Diseases
LAB0160: Antiparasitic and Antimicrobial Agents
PCT No. PCT/US2016/035896 issued on

Malaria, a mosquito-borne parasitic disease, affects 3.3 billion people worldwide where 214 million cases were reported in 2015 alone. With a 90% mortality rate in Africa and increasing rates of infections, an alternative method of  treatment is needed. Our inventor has designed a potent peptide that exhibits antiparasitic effects on one of the major strains responsible for Malaria infection, p. falciparum. This strain is also responsible for the most severe and complicated cases associated with high mortality. The invention has shown potent efficacy in the treatment of p.

Infectious Diseases
LAB0165: Aerosolized Synthetic Lung Surfactant
Provisional Application No. 62/268,800 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Neonatology
LAB0010: Mammalian Receptors as Targets for Antibody and Active Vaccination Therapy Against Mold Infections
US Patent No. 9,259,467 issued on

The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include antibody, antibody fragment, siRNA and vaccine compositions having or directed against a GRP78 polypeptide or an antigenic fragment of the polypeptide.

Infectious Diseases
LAB0018: Compositions and Methods for Immunization Against Bacteria Expressing A Carbapenemase
US Patent No. 9,167,477 issued on

The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial infections. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase, or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention.

Infectious Diseases
LAB0019: Methods and Compositions for Treatment of Multidrug-resistant Bacterial and Fungal Infections
PCT No. PCT/US2013/031284 filed on

The invention provides a method of killing an infectious microbe by administering an effective amount of transferrin to an individual having a microbial infection, wherein the transferrin has microbicidal activity, thereby reducing survival of the infectious microbe in the individual.

Infectious Diseases
LAB0044: Vaccination with Killed but Metabolically Active (KBMA) Protozoans with Toll-like Receptor Agonists
US Patent No. 8,709,445 issued on

This invention provides compositions for inducing an immune response in a vertebrate host against a protozoan parasite. In certain embodiments the composition comprises a protozoan parasite comprising a psoralen-modified DNA, whereby said protozoan parasite is killed but metabolically active (KBMA); and optionally a Toll-like receptor agonist.

Infectious Diseases
LAB0144: Prevention and Treatment of Invasive Aspergillosis
PCT No. PCT/US16/13483 filed on

A novel peptide-based prevention and treatment of invasive aspergillosis (fungal).

Embodiments disclosed herein relate to compositions comprising extracellular thaumatin domain proteins, or portions thereof (e.g., CalA polypeptides, or portions thereof), and compositions comprising binding agents (e.g., antibodies, fragments thereof, and the like) that bind specifically to CalA polypeptides, and methods of using the same for preventing or treating a fungal infection.

Infectious Diseases
LAB0013: Anti-Infective Hydroxyphenyl Benzoates and Methods of Use
US Patent No. 8,809,263 issued on
US Patent No. 9,205,097 issued on

The invention provides a method for preventing or treating a disease caused by an extracellular microorganism. Said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (SAL) or a SAL analog. The extracellular microorganism can be of the bacterial genus Staphylococcus. The extracellular microorganism can be a strain that is resistant to at least one antibiotic.

Infectious Diseases
LAB0033: Humanin, Analogs and Cancer Treatment Methods and Uses Thereof
US Patent Application No. 14/645,315 filed on

Described herein are methods of protecting germ cells in a subject from cell death induced by a chemotherapeutic agent by, in part, administering a composition comprising one or more humanin polypeptides to the subject. Also described herein are methods of inhibiting a reduction or decrease in fertility in a subject wherein the reduction or decrease in fertility is due to a chemotherapeutic agent.

Oncology
LAB0034: Compositions and Methods for Reducing Germ Cell Apoptosis
PCT No. PCT/US2015/20013 filed on

Described herein are methods of protecting germ cells in a subject from cell death induced by a chemotherapeutic agent by, in part, administering a composition comprising one or more humanin polypeptides to the subject. Also described herein are methods of inhibiting a reduction or decrease in fertility in a subject wherein the reduction or decrease in fertility is due to a chemotherapeutic agent.

Oncology
LAB0043: Treatment for Nicotine-Induced Lung Disease Using Peroxisome Proliferator-Activated Receptor Gamma Agonists
US Patent No. 9,173,875 issued on

A method of reducing, eliminating, and/or reversing pulmonary tissue damage characterized by smoke-induced pulmonary alveolar trans-differentiation of lipofibroblasts to myofibroblasts in utero in a developing fetus carried by a pregnant mammal. Said method comprising a PPAR gamma (PPARγ) agonist to said pregnant mammal in an amount sufficient to reduce, eliminate, or reverse said transdifferentiation.

Neonatology Pediatrics Pulmonary
LAB0052: Treatment of Peritoneal Injury Using JAK Inhibitors
US Patent No. 9,198,900 issued on

Methods to treat and prevent peritoneal injury using JAK inhibitors. The invention provides, in certain embodiments, a method of preventing and/or treating peritoneal injury and/or diminished function by administering an effective amount of one or more inhibitors of JAK. The invention also provides a pharmaceutical composition including a JAK inhibitor for the treatment of peritoneal injury and/or diminished function. In another aspect, the invention provides a method of detecting an indicator of peritoneal injury.

Nephrology
LAB0055: Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie’s Disease, Arteriosclerosis, and Other Fibrotic Diseases
US Patent No. 8,133,903 issued on

The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hyp

LAB0060: Composition and Method for Cancer Chemoprevention
US Patent No. 8,658,160 issued on

A composition including an effective amount of a treatment agent to inhibit tumor growth in a mammal by manipulating a prostaglandin D2 biosynthetic pathway. A method comprising introducing an effective amount of a treatment agent to a mammal to inhibit tumor growth by manipulating a prostaglandin D2 biosynthetic pathway while at the same time reducing production of other forms of prostaglandins that may produce ill effects, such as prostaglandin E2.

Oncology
LAB0099: Compositions, Methods and Uses for Protecting White Blood Cells from Suppression or Death
PCT No. PCT/US15/050029 filed on

Provided herein are compositions, methods and uses of humanin or a humanin analog in treating a subject with humanin to protect white blood cells from suppression or cell death induced by an autoimmune, anti-tumor or anti-cancer therapeutic agent.

Hemotology Oncology
LAB0161: Humanin Compositions, Methods and Uses for Protecting Heart from Stress and Chemotherapy
PCT No. PCT/US16/50780 filed on

The invention is a method of reducing, decreasing or inhibiting cardiotoxicity in a subject from an anti-cancer therapeutic agent suppression or death, where cardiotoxicity is induced, promoted, increased stimulated by anti-cancer treatment in conjunction with humanin, or a humanin analog to protect, reduce, decrease or inhibit cardiotoxicity.

Cardiology Oncology
LAB0162: Proteaosome Activation for Cornea Blindness Treatment
Provisional Application No. 62/255,338 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Ophthalmology

Biomarker

LAB0050: Use of Periostin As a Novel Biomarker
US Patent No. 8,592,223 issued on

The invention provides, in certain embodiments, a method of assaying an indicator of, and treating, renal injury or renal disease. The method entails assaying a urine sample for periostin, wherein the presence of periostin at an elevated level indicates the presence and/or degree of renal injury or renal disease. The method also involves prescribing, initiating, or altering prophylaxis or therapy for renal injury or renal disease. Also provided, are methods of determining progression of these conditions, as well as methods of determining subjects' response to treatment.

LAB0047: Use of Hematopoietic Growth Factor Inducible Neurokinin-I (HGFIN) as a Biomarker for Renal Injury or Renal Disease
US Patent No. 8,460,884 issued on

The invention provides, in certain embodiments, a method of detecting an indicator of renal injury or renal disease. The method entails assaying a urine sample for hematopoietic growth factor inducible neurokinin-1 (HGFIN), wherein the presence of HGFIN at an elevated level indicates the presence and/or degree of renal injury or renal disease, and/or the rate of loss of renal function. In other embodiments, the invention provides a method of detecting an indicator of systemic inflammation.

Nephrology

Diagnostic/Prognostic

LAB0027: Method of Inhibiting Lipofibroblast To Myofibroblast Transdifferentiation
US Patent No. 6,992,093 issued on

Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.

LAB0029: Prognostic Assays for Maintenance Hemodialysis Patients
US Patent Application No. 13/283,536 filed on

Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring.

Nephrology
LAB0040: Use of Parathyroid Hormone-related Protein (PTHrP) In the Diagnosis and Treatment of Chronic Lung Disease and Other Pathologies
US Patent No. 8,293,479 issued on

This invention pertains to the discovery that Parathyroid Hormone-related Protein (PTHrP) can be detect and/or stage, and/or treat chronic lung diseases. In particular, it was discovered that PTHrP levels in broncho-alveolar lavage are indicative of lung “health” and “disease,” and can be used to predict lung disease in patients at risk of chronic lung disease and/or to evaluate the efficacy of a ventilation regime.

Medical Devices

LAB0157: Multi-Branched In-Line Thoracic-Abdominal Endoluminal Graft and In-Line Fabrication Mandrel
Provisional Application No. 62/327,600 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Cardiology
LAB0140: An Integrated Fiber Optic Sensor Umbilical (ISUM) Catheter for Blood Gas Monitoring in Neonates
Provisional Application No. 62/368,951 filed on

As this application has not been published yet by the patent office, details are only available under a confidentiality agreement.

Neonatology
LAB0037: Device and Method for Screening Congenital Heart Disease
US Patent No. 8,892,196 issued on

An apparatus including a main processing unit. The apparatus further including a precordial patch coupled to the main processing unit, the precordial patch having a plurality of sensors for detecting heart sounds and cardiac electrical signals (ECG). The apparatus further including a probe coupled to the main processing unit, the probe having a sensor for detecting oxygen saturation of blood circulating through a human.

Cardiology Neonatology Pediatrics
LAB0063: ECG Lead System for Newborn ECG Screening
US Patent No. 8,369,924 issued on
US Patent No. 8,660,630 issued on

An apparatus including a chest strip including a plurality of precordial leads positioned to correspond with desired lead placement for an electrocardiogram; and a plurality of limb leads coupled to the chest strip.

Cardiology Neonatology Pediatrics
LAB0031: Apparatus, Systems and Methods for Detecting Congenital Heart Disease in Newborns
US Patent Application No. 14/515,820 filed on

Apparatus configured to detect congenital heart disease (CHD) in newborns may comprise a body with a cavity configured to receive a hand or foot of a newborn. Sensor pairs of the apparatus may be configured scan such that the best signals can be selected, which can accommodate for movements of the newborn and/or facilitate impartialness as to which body part is inserted in the apparatus. Positions of the sensor pairs may be adjusted to ensure contact with the newborn's skin. A disposable cover may protect the newborn's skin from contacting the apparatus.

Cardiology Neonatology Pediatrics
LAB0035: Systems, Apparatus and Methods for Documenting Code Blue Scenarios
PCT No. PCT/US2015/024352 filed on

An apparatus may be configured for documenting a code blue scenario when adhered to the chest of a subject undergoing resuscitation by sensing and transmitting information associated with the code blue scenario. Such information may include one or more of vital signs of the subject during resuscitation, information associated with chest movements of the subject during resuscitation, and audio information from an environment of the subject during resuscitation.

Emergency Medicine
LAB0038: Foot Pulse Oximeter for Screening Congenital Heart Disease Before Newborn Discharge
US Patent Application No. 13/216,150 filed on

A method including placing a portion of a foot of a newborn in a device, the device including a light emitter and a corresponding receiver coupled on opposite sides of the device, the device further including a processor for processing data from the light emitter and receiver; and determining a presence of congenital heart disease.

Cardiology Neonatology Pediatrics
LAB0070: SIDS Monitor
US Patent Application No. 13/957,308 filed on
Pediatrics
LAB0090: Conjunctival Monitor
US Patent No. 6,973,338 issued on

A method for monitoring blood/tissue gases, blood pH, and other elements of blood and tissue chemistry is described that uses a sensor tip that is placed adjacent to the conjunctiva of a patient to be monitored. Monitors and sensor using optical fiber sensors for performing the monitoring are also described.

Emergency Medicine Neonatology
LAB0108: Wearable Device for Diagnosis and Assessment of Asthma
PCT No. PCT/US15/52711 filed on

Exemplary implementations may provide objective, continuous, and clinically useful assessment of asthma control in subjects including young children using a device that is compact, non-intrusive, and simple. The device may include a water-resistant, flexible patch that can be comfortably worn for two weeks or more. In some implementations, the patch may resemble a Band-Aid® that is placed on the supra-sternal notch. The device may record respiratory sounds that can be analyzed to identify coughing and wheezing episodes.

Pediatrics Pulmonary
LAB0156: Integrated Compact 12-Lead ECG System to Minimize Errors and Enable Home Use
PCT No. PCT/US16/27246 filed on

A novel wearable device (12 lead ECG) to monitor heart condition at home. 

Cardiology Neonatology Pediatrics
LAB0071: Device to Secure Airway During Emergency Care
US Patent Application No. 14/135,325 filed on

An airway management device including a tubular member dimensioned for introducing air into a trachea of a mammal, the tubular member having a proximal portion, a distal portion, and a middle portion between the proximal portion and the distal portion. The tubular member is dimensioned for positioning of the proximal portion in an oral cavity of a mammal, the middle portion in an oropharynx of the mammal and the distal portion in an esophagus of the mammal. An inflatable oral cavity balloon is positioned at the proximal portion and dimensioned to occlude the oral cavity.

Emergency Medicine Pulmonary
LAB0073: Device to Ensure Successful Endotrachael Intubation
US Patent Application No. 14/206,137 filed on

An apparatus including an accelerometer and a microphone contained in a housing that can be placed on a chest of an individual, the accelerometer configured to detect chest motion and microphone to detect respiratory sounds during at least one of inspiration and expiration. A method including placing such an apparatus on a chest of a subject. A method of monitoring an intubation including simultaneously assessing chest movement and air movement sounds in the airway and lungs; and indicating the status of the intubation based on the assessing.

Emergency Medicine Pulmonary
LAB0075: Surfactant Administration and Airway for Premature Infants
US Patent Application No. 14/135,331 filed on

A fluid delivery and airway management device including a tubular member dimensioned for introducing a fluid into a trachea of a mammal, the tubular member having a proximal portion, a distal portion, and a middle portion between the proximal portion and the distal portion. The tubular member is dimensioned for positioning of the proximal portion in an oral cavity of a mammal, the middle portion in an oropharynx of the mammal and the distal portion in an esophagus of the mammal.

Neonatology Pediatrics Pulmonary
LAB0109: Valve-assisted Limited Ventilation (Valve) Device
PCT No. PCT/US2016/015803 filed on

A novel medical device that can be used to treat children under emergency situations. An overinflation and/or overventilation device includes a body configured to attach to a resuscitation interface and a gas source, a subject metric input component disposed at the body, the subject metric input component configured to receive input specifying a metric associated with a resuscitation subject; and a volume control mechanism disposed within the body, the volume control mechanism configured to control a volume of gas provided by the gas source during a manual resuscitation that is communicated

Pediatrics Pulmonary

Software/Algorithm

LAB0056: Method and System for Measuring Amniotic Fluid Volume and/or Assessing Fetal Weight
US Patent No. 7,399,278 issued on

A system is described for measuring amniotic fluid volume and/or assessing fetal weight. The system includes an ultrasound apparatus to scan a pregnant uterus and to generate data representative of a three-dimensional construction of the scanned uterus, and a processor to compute a volume of amniotic fluid or weight of fetal tissue based on the three-dimensional construction of the scanned uterus. Also a method of computing a volume of amniotic fluid and/or a weight of fetal tissue.

Neonatology OBGYN
LAB0057: Exercise Test Speed and Grade Modification
US Patent No. 7,628,732 issued on
US Patent No. 7,927,251 issued on

A treadmill test protocol is provided having a linearly increasing work rate profile achieved by increasing walking speed while simultaneously increasing treadmill inclination. Specifically, according to the protocol it is possible to use a test subject's projected maximum end-test work rate to calculate a treadmill test protocol having a linear increase in walking speed and simultaneous curvilinear increase in treadmill grade so that when the test subject is tested according to the calculated protocol, the test result yields a work rate and oxygen uptake response with a linear slope.

Pulmonary
LAB0059: Method and System for Detection of Respiratory Variation in Plethysmographic Oximetry
US Patent No. 8,128,569 issued on
US Patent No. 8,465,434 issued on

A method and system for detection of respiratory variation in pulse oximetry are provided. In one embodiment, the method includes detecting a pattern consistent with a respiratory cycle of a waveform representing cardiac oscillations and identifying an abnormality based on the pattern. The method further includes triggering an alarm in response to identifying an abnormality. A system is further provided including a database and a module.

Cardiology
LAB0066: Method and System for Automated Measurement of Pulsus Paradoxus
US Patent Application No. 12/604,346 filed on

A method and system for automatically detecting pulsus paradoxus. In one embodiment, the method includes automatically detecting pulsus paradoxus based upon a consideration of a blood pressure component, an audio component indicative of Korotkoff sounds and a respiratory component. The system includes a plurality of input modules for determining a blood pressure, a Korotkoff sound and a respiration of a subject.

Cardiology
LAB0067: Method for Thoracic Vertebral Bone Density Measurement by Thoracic Quantitative Computed Tomography
US Patent No. 9,119,590 issued on

Quantitative computed tomography (QCT) is the currently used technique for three-dimensional BMD measurement. Since bone density can be measured in trabecular and cortical bone compartments, thoracic QCT is an important technique for estimating and monitoring bone strength, especially bone mineral density (BMD) measurement. There is a significant positive association between BMD values obtained from the thoracic and lumbar spinal vertebrae.

Cardiology
LAB0068: Use of Relatively Permanent Pigmented or Vascular Skin Mark Patterns in Images for Personal Identification
US Patent No. 8,787,625 issued on

Embodiments include methods, devices, software, and systems for identifying a person based on relatively permanent pigmented or vascular skin mark (RPPVSM) patterns in images. Locations of RPPVSMs in different images of people are point matched, and a correspondence probability that the point matched RPPVSMs are from different people is calculated. Other embodiments are also described and claimed.

Dermatology
LAB0143: Method and an Apparatus for Determining Vein Patterns from a Color Image
PCT No. PCT/SG2011/000429 filed on

The present invention is directed to a method of determining vein patterns from a color image for personal identification, the method comprising forming a counterpart of the color image by applying a functional relationship obtained from optimization on the color image, wherein the counterpart of the color image comprises the vein patterns. An apparatus for determining vein patterns from a color image is also disclosed.

Dermatology

Research Tool

LAB0065: A Stable Isotope Labeling Method for Determination of Protein Synthesis and Protein Expression in the Study of Biological Effects of Drugs and Other Biological Agents
US Patent No. 8,574,543 issued on

A method including isotope labeling of a newly synthesized protein in a sufficient quantity such that a newly synthesized protein spectra and the pre-existing protein spectra are sufficiently separated. A further method including determining a ratio of a new and a pre-existing protein from mass spectra obtained by using mass spectrometry. In this method a resultant spectrum may be presented as integrated peak heights for a corresponding mass to charge ratio in the “centroid” mode.