Nagendra N Mishra, PhD
Assistant Professor of Research, David Geffen School of Medicine at UCLA
Research DescriptionDr. Mishra's research focuses on the growing health issue of antimicrobial resistance, which threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. He has recently identified adaptations associated with lipid membranes of Candida, Staphylococci, Enterococci and Streptococci that confer resistance to certain antibiotics in vitro and in vivo.
He also discovered the significance of Staphylococcal carotenoid augmented membrane fluidity/rigidity and its implications in resistance to host defense peptides and in vivo virulence in an endocarditis model. Further understanding microbial adaptation to the host in the setting of anti-infective agents aims to open new doors to anti-infective strategies addressing the current challenge of conventional antibiotic resistance.
- PhD, University of Allahabad, India
Recent and/or Significant Publications
- Xiong YQ, Yang SJ, Tong SY, Alvarez DN, Mishra NN. The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathog Dis. 2015 Oct;73(7). pii: ftv056. doi: 10.1093/femspd/ftv056. Epub 2015 Aug 4.PMID: 26242278
- Bayer AS, Mishra NN, Chen L, Kreiswirth BN, Rubio A, Yang SJ. Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides. Antimicrob Agents Chemother. 2015 Aug;59(8):4930-7. doi: 10.1128/AAC.00970-15. Epub 2015 Jun 8. PMID: 26055370
- Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ. Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother. 2014 Dec;58(12):7462-7. doi: 10.1128/AAC.03422-14. Epub 2014 Oct 6. PMID: 25288091