Margaret A Keller, MD
Professor of Pediatrics, David Geffen School of Medicine at UCLA
Chief, Pediatric Infectious Diseases, Harbor-UCLA Medical Center
Director, Program for Pediatric HIV, Harbor-UCLA Medical Center
Chair, Bioethics Committee of Harbor-UCLA Medical Center
HIV–infection in children, adolescents, and pregnant woman
Research DescriptionDr. Keller's research is focused on developing effective, non-invasive tools to detect the harmful effects of HIV on the central nervous system of perinatally infected children and youth. There is a critical need to improve detection of HIV brain damage since current methodologies such as CT scan and MRI fail to reveal abnormalities in cerebral metabolites, resulting in HIV-infected young people receiving ineffective treatments that takes both a financial and an emotional toll on families and their medical support community. Dr. Keller is working to develop a one- and two-dimensional magnetic resonance spectroscopy (MRS) to be used in HIV-infected youths, in which the finding will be correlated with neuropsychological test results. In addition to her work on MRS techniques, Dr. Keller studies intervention strategies to prevent maternal transmission of HIV to the infant.
- MD, 1972, Albert Einstein College of Medicine, New York, NY
Recent and/or Significant Publications
- Gershon A.A., Levin M.J., Weinberg A., Song L.Y., Larussa P.S., Steinberg S.P., Bartlett P. A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella.For the Pediatric AIDS Clinical Trials Group 391 Team. Pediatr Infect Dis J. 2009 July;28(7)653-655.
- Andiman W.A., Chernoff M.D., Mitchell C., Purswani M., Oleske J., Williams P.L., Spiegel H., Gona P., Seage G.R. Incidence of Persistent Renal Dysfunction in Human Immunodeficiency Virus-Infected Children. Associations With the Use of Antiretrovirals and Other Nephrotoxic Medications and Risk Factors. For the PACTG iDACS 617 Study Team. The Pediatric Infectious Disease Journal, 2009;28(3);619-625.
- Butler AM, Williams PL, Howland LC, Storm D, Hutton N, Seage GR. Impact of Disclosure of HIV Infection on Health-Related Quality of Life Among Children and Adolescents with HIV Infection.3rd; Pediatric AIDS Clinical Trials Group 219C Study Team.