Lynda E Polgreen, MD, MS
Assistant Professor of Pediatrics, David Geffen School of Medicine at UCLA
Pediatric bone disease
Research DescriptionDr. Polgreen’s research focuses on ways to improve the treatment and understanding of rare pediatric bone diseases. She performs clinical research investigating the skeletal pathology and bone metabolism in the Mucopolysaccharidoses (MPS) a class of lysosomal storage diseases, a sclerotic bone disease called osteopetrosis, and the immunological effects of vitamin D. Active projects include identification of biomarkers that predict disease severity in MPS and of inflammatory pathways involved in MPS related skeletal disease, a clinical trial of anti-inflammatory therapy in MPS, a clinical trial of interferon gamma in osteopetrosis, and a study to explore the role of vitamin D in the immune response to malaria infection.
- BS, 1996, University of Minnesota, Minneapolis, MN
- MD, 2002, Mount Sinai School of Medicine, New York, NY
- MS, 2009, University of Minnesota, Minneapolis, MN
Recent and/or Significant Publications
- Polgreen LE, Vehe RK, Rudser K, Kunin-Batson A, Utz JJ, Dickson P, Shapiro E, Whitley CB. Elevated TNF-α is associated with pain and physical disability in mucopolysaccharidosis types I, II, and VI. Mol Genet Metab. 2016 Apr;117(4):427-30. doi: 10.1016/j.ymgme.2016.01.012. Epub 2016 Jan 28.
- Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE. Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS One. 2014 Dec 3;9(12):e113185. doi: 10.1371/journal.pone.0113185. eCollection 2014.
- Polgreen LE, Thomas W, Orchard PJ, Whitley CB, Miller BS. Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2 years in children with Hurler or Hunter syndrome.Mol Genet Metab. 2014 Feb;111(2):101-6. doi: 10.1016/j.ymgme.2013.11.013. Epub 2013 Dec 11
- Polgreen LE, Thomas W, Fung E, Viskochil D, Stevenson DA, Steinberger J, Orchard P, Whitley CB, Ensrud KE. Low bone mineral content and challenges in interpretation of dual-energy X-ray absorptiometry in children with mucopolysaccharidosis types I, II, and VI. J Clin Densitom. 2014 Jan-Mar;17(1):200-6. doi: 10.1016/j.jocd.2013.03.004. Epub 2013 Apr 2.