Joseph Lasky, MD
Associate Clinical Professor of Pediatrics and Neurosurgery, David Geffen School of Medicine at UCLA
Department of Pediatrics, Harbor-UCLA Medical Center
Pediatric hematology and oncology
Research DescriptionCancer afflicts 12,000 children per year in the United States. Although current therapies can cure over 80% of these children, many are left with devastating long term side effects. Dr. Lasky's research team is interested in using genomic, epigenetic, metabolomic, and immunologic approaches in a clinical, translational, and basic science to target childhood cancers more effectively and in a less toxic fashion. Specifically, Dr. Lasky's team has studied sensitized T-lymphocytes in animal models as an adoptive immunotherapy in combination with chemotherapy as well as metabolic inhibitors in combination with other therapies to slow or stop tumor growth.
In addition to oncology, Dr. Lasky also participate in clinical and translational work in sickle cell disease (SCD). Over 100,000 people in the United States suffer from sickle cell disease and its complications (such as pain, kidney failure, and decreased life span). He is working with other researchers at LA BioMed to discover novel therapies to ameliorate the complications of this disease.
- Double BS, 1996, University of Illinois, Urbana, IL
- MD, 2000, University of Illinois, Chicago, IL
Recent and/or Significant Publications
- Lasky J, Nakano I. Cancer Stem Cells in Brain Tumors. Curr Signal Transduct Ther;8(1):45-54.2013
- Lasky JL, Panosyan EH, Plant A, Davidson T, Yong WH, Prins RM, Liau LM, Moore TB. Autologous Tumor Lysate-pulsed Dendritic Cell Immunotherapy for Pediatric Patients with Newly Diagnosed or Recurrent High-grade Gliomas. Anticancer Research. May 1, 2013;33(5):2047-56.2013
- Venkatramani R, Ji L, Lasky J, Haley K, Judkins A, Zhou S, Sposto R, Olshefski R, Garvin J, Tekautz T, Kennedy G, Rassekh S, Moore T, Gardner S, Allen J, Shore R, Moertel C, Atlas M, Dhall G, Finlay J. Outcome of infants and young children with newly diagnosed ependymoma treated on the “Head Start” III prospective clinical trial. Journal of Neuro-Oncology. 2013/03/19:1-7.2013
- Panosyan EH, Wang Y, Xia P, Lee W-NP, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI and Lasky JL. Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors. Molecular Cancer Research, 2014.