Henry J. Lin, MD
Investigator, The Lundquist Institute
Professor of Pediatrics, David Geffen School of Medicine at UCLA
Chief, Division of Medical Genetics, Harbor-UCLA Medical Center
Contact
Email
Genomic studies of heart diseases; medical genetics
Research Description
Since 2014, Dr. Lin's research has been within the Institute for Translational Genomics and Population Sciences -- mainly on genetics of heart rhythm conditions, including long QT syndrome, atrial fibrillation, and electrocardiographic traits (e.g., heart rate, PR, QRS, QT, and ectopy). In another area, Drs. Lin and Ruey-Kang Chang finished a clinical study of newborn screening for long QT syndrome by use of a one-piece ECG electrode strip and compact ECG recorder -- both invented by Dr. Chang and colleagues for newborns. A manuscript on use of the novel ECG system by parents on their own babies will be submitted soon (covering 2,582 newborns). The papers will include the first genome-wide association study of ECG traits in normal newborns and the first newborn screening study of long QT syndrome in the United States.Past research focused on factors that may play a role in the prevention of intestinal tumors, as in hereditary polyposis or colon cancer. His lab has studied the role of prostaglandin D2 as a tumor preventing molecule. Other activities cover genetic disorders, including malformation syndromes and inborn errors of metabolism.
Theme Groups
Research Interests
Education
- AB, University of California, Berkeley
- MD, Harvard Medical School, Boston, MA
Recent and/or Significant Publications
Rotter JI, Lin HJ. An Outbreak of Polygenic Scores for Coronary Artery Disease. J Am Coll Cardiol. 2020;75(22):2781-2784. doi:10.1016/j.jacc.2020.04.054
Collins RL, Brand H, Karczewski KJ, Zhao X, Alföldi J, Francioli LC, Khera AV, Lowther C, Gauthier LD, Wang H, Watts NA, Solomonson M, O'Donnell-Luria A, Baumann A, Munshi R, Walker M, Whelan CW, Huang Y, Brookings T, Sharpe T, Stone MR, Valkanas E, Fu J, Tiao G, Laricchia KM, Ruano-Rubio V, Stevens C, Gupta N, Cusick C, Margolin L; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Taylor KD, Lin HJ, Rich SS, Post WS, Chen YI, Rotter JI, Nusbaum C, Philippakis A, Lander E, Gabriel S, Neale BM, Kathiresan S, Daly MJ, Banks E, MacArthur DG, Talkowski ME. A structural variation reference for medical and population genetics. Nature. 2020;581(7809):444-451. doi:10.1038/s41586-020-2287-8
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen LP, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S, Yao J, Zilhao NR, Brody JA, Braund PS, Brumat M, Campana E, Christofidou P, Caulfield MJ, De Grandi A, Dominiczak AF, Doney ASF, Eiriksdottir G, Ellervik C, Giatti L, Gögele M, Graff C, Guo X, van der Harst P, Joshi PK, Kähönen M, Kestenbaum B, Lima-Costa MF, Linneberg A, Maan AC, Meitinger T, Padmanabhan S, Pattaro C, Peters A, Petersmann A, Sever P, Sinner MF, Shen X, Stanton A, Strauch K, Soliman EZ, Tarasov KV, Taylor KD, Thio CHL, Uitterlinden AG, Vaccargiu S, Waldenberger M, Robino A, Correa A, Cucca F, Cummings SR, Dörr M, Girotto G, Gudnason V, Hansen T, Heckbert SR, Juhl CR, Kääb S, Lehtimäki T, Liu Y, Lotufo PA, Palmer CNA, Pirastu M, Pramstaller PP, Ribeiro ALP, Rotter JI, Samani NJ, Snieder H, Spector TD, Stricker BH, Verweij N, Wilson JF, Wilson JG, Jukema JW, Tinker A, Newton-Cheh CH, Sotoodehnia N, Mook-Kanamori DO, Munroe PB, Warren HR. Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. J Am Coll Cardiol. 2019;73(24):3118-3131. doi:10.1016/j.jacc.2019.03.519
Lin HJ, Lan YT, Silka MJ, Halnon NJ, Villa-Lopez E, Arenas N, Escobedo F, Montoya R, Valdez S, Rajabi Shishvan O, Sedano S, Marr EH, Lauzon M, Moosa AS, Ko KJ, Shoji EC, Clark AM, Smith LM, Criley JM, Grody WW, Chen YI, Taylor KD, Guo X, Soyata T, Rotter JI, Chien T, Chou P, Chang RK. Home use of a compact, 12‑lead ECG recording system for newborns. J Electrocardiol. 2019;53:89-94. doi:10.1016/j.jelectrocard.2019.01.086
Lin HJ, Lehoang J, Kwan I, Baghaee A, Prasad P, Ha-Chen S, Moss T, Woods JD. Lego bricks and the octet rule: Molecular models for biochemical pathways with plastic, interlocking toy bricks. Biochem Mol Biol Educ. 2018;46(1):54-57. doi:10.1002/bmb.21090