Delphine J Lee, MD, PhD
Chief and Residency Program Director
Division of Dermatology, Department of Medicine, Harbor-UCLA Medical Center
Translational Immunology, Microbiome
Research DescriptionDr. Lee is a dermatologist and immunologist who uses molecular and bioinformatic approaches at the site of disease to uncover mechanisms regulating human immunity as they relate to cancer, infections, and autoimmunity. Dr. Lee recently led her research team from John Wayne Cancer Institute with collaborators at the Dr. Susan Love Research Foundation and JPL NASA to publish the first report of the human breast ductal microbiome in healthy subjects versus breast cancer survivors. Her innovative research in metastatic melanoma has shown that the immune system plays a key role in long-term survival, long before the advent of checkpoint blockade.
- MD, PHD, University of California, San Diego
- Lee DJ, Xuan C. Methods of diagnosing and treating cancer by detecting and manipulating microbes in tumors. PCT/US13/78550, 14145853, filed December 31, 2013.
Recent and/or Significant Publications
- Lardone RD, Plaisier SB, Navarrete MS, Shamonki JM, Jalas JR, Sieling PA, Lee DJ. Cross-platform comparison of independent datasets identifies an immune signature associated with improved survival in metastatic melanoma. Oncotarget. 2016; 7(12):14415-28.
- Chan AA, Bashir M, Rivas MN, Duvall K, Sieling PA, Pieber TR, Vaishampayan PA, Love SM, Lee DJ. Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors. Scientific reports. 2016; 6:28061.
- Flaherty DC, Lavotshkin S, Jalas JR, Torisu-Itakura H, Kirchoff DD, Sim MS, Lee DJ, Bilchik AJ. Prognostic Utility of Immunoprofiling in Colon Cancer: Results from a Prospective, Multicenter Nodal Ultrastaging Trial. Journal of the American College of Surgeons. 2016; 223(1):134-40.
- Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science (New York, N.Y.). 2013; 339(6126):1448-53.