Begoña Díaz, PhD
Assistant Professor of Medicine, David Geffen School of Medicine at UCLA
Division of Medical Oncology Hematology, Harbor-UCLA Medical Center
Understanding and Targeting Cancer Cell Invasion and Metastasis
Research DescriptionDr. Díaz's laboratory investigates the molecular and cellular mechanisms that promote cancer cell invasiveness with the goal of utilizing this knowledge to uncover novel therapeutic targets to restrain metastasis.
They are currently focusing on investigating how tumor microenvironmental conditions, such as hypoxia, regulate cell-cell communication events that promote cancer cell invasion and therapeutic resistance.
- PhD, 1999, Autonomous University, Madrid, Spain
Recent and/or Significant Publications
- B. Díaz, K.T. Ostapoff, J.E. Toombs, J. Lo, M.Y. Bonner, A. Curatolo, V. Adsay, R.A. Brekken, J.L. Arbiser. Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an ortothopic model. Oncotarget, 2016, Jul 9. doi: 10.18632/oncotarget.10514
- P. Cejudo-Martin, A. Yuen, N.Vlahovich, P.Lock, S.A. Courtneidge and B. Díaz. Genetic disruption of the Sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of Tks5. PLoS One, 2014, 9(9): e107674.
- B. Díaz, A. Yuen, S. Iizuka, S. Higashiyama and SA. Courtneidge. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. Journal of Cell Biology, 2013, 201 (2), 279-292.