Ashraf S Ibrahim, PhD
Professor of Medicine, David Geffen School of Medicine at UCLA
Infectious Disease Faculty member at Harbor-UCLA Medical Center
Pathogenic mechanisms of fungal and bacterial infections
Research DescriptionDr. Ibrahim’s research focuses on advancing the understanding of the pathogenic mechanisms and virulence factors of fungal and bacterial infections, and on translating this knowledge into novel immunotherapeutic strategies to combat infectious diseases. His research programs on the pathogenesis of the fatal fungal infection, mucormycosis and the multidrug resistant Acinetobacter virulence are NIH funded.
He coauthored more than 120 peer-reviewed research papers, book chapters and review articles and serves as an Ad Hoc reviewer of numerous peer-reviewed Journals as well as a temporary reviewer of several study sections at the NIH. Dr. Ibrahim is the recipient of numerous awards including the prestigious Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Program Committee Award in the area of Therapy and Prevention of Microbial Disease.
- PhD, 1991, Microbial Physiology, Loughborough University of Technology in Loughborough, England
Recent and/or Significant Publications
- Liu M, Spellberg B, Phan Q, Fu Y, Fu Y, Lee A, Edwards Jr. J, Filler S, Ibrahim AS (2010). The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. Journal of Clinical Investigation. 120:1914-24. PMCID: PMC2877958.
- Gebremariam T, Liu M, Luo G, Bruno V, Phan QT, Waring AJ, Edwards Jr. JE, Filler SG, Yeaman MR, Ibrahim AS (2014). CotH3 mediates fungal invasion of host cells during mucormycosis. Journal of Clinical Investigation. Jan 2;124(1):237-50. PMCID: PMC3871245.
- Yeaman MR, Filler SG, Chaili S, Barr K, Wang H, Kupferwasser D, Hennessey Jr.JP, Fu Y, Schmidt CS, Edwards Jr. JE, Xiong YQ, Ibrahim AS (2014). Efficacy and Immune Mechanisms of the NDV-3 Vaccine in a Murine Model of MRSA Skin / Skin Structure Infection. Proc Natl Acad Sci U S A. pii: 201415610. [Epub ahead of print] PMCID: PMC4280579.
- Liu M, Lin L, Gebremariam T, Luo G, Skory CD, French SW, Chou T-F, Edwards, Jr. JE, Ibrahim AS. Fob1 and Fob2 Proteins are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine. PLoS Pathogens 2015 May 14;11(5):e1004842. doi: 10.1371/journal.ppat.1004842. eCollection 2015 May. PMID:25974051