Arnold S Bayer, MD
Distinguished Professor of Medicine, David Geffen School of Medicine at UCLA
Bacterial pathogenesis; Relationships of host defense peptides to endovascular infections
Research DescriptionDr. Bayer is a renowned expert and key opinion leader in bacterial pathogenesis, antibiotic resistance, animal models of infection, and therapeutic optimization as it relates to endovascular infections. His lab studies how the human body responds to infection and builds up resistance to antibiotics. His main area of focus is the expression of key virulence factors and genes which enhance the ability of Staphylococcus aureus to cause endovascular infections and resist antibiotics. Additionally, Dr. Bayer is investigating the mechanisms by which platelet peptides kill common blood stream pathogens, and the genetic mechanisms by which certain strains of bacteria develop resistance and cross-resistance to antibiotics. The ultimate goal of his research is to develop strategies to effectively circumvent pathogens as well as drug resistances.
- MD, 1970, Temple University School of Medicine
Recent and/or Significant Publications
- Bayer AS, Mishra NN, Chen L, Kreiswirth BN, Rubio A, Yang SJ. Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides. Antimicrob Agents Chemother. 2015 Aug; 59(8):4930-7.
- Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ. Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother. 2014 Dec; 58(12):7462-7.
- Mishra NN, Yang SJ, Chen L, Muller C, Saleh-Mghir A, Kuhn S, Peschel A, Yeaman MR, Nast CC, Kreiswirth BN, Crémieux AC, Bayer AS. Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms. PLoS One. 2013 Aug 19;8(8):e71151.