Research DescriptionHIV associated neurocognitive disorder (HAND) continues to be a devastating problem for HIV seropositive individuals despite currently available antiretroviral treatment options that allow successful systemic viral suppression for many patients. The mechanisms causing neuronal dysfunction in HAND, and the relationship between HAND and aging are not fully understood. My research focuses on improving understanding of the pathogenesis of this disorder and its interaction with the aging process, specifically the contribution of cerebral white matter damage to HIV related cognitive dysfunction.
- BA, 1996, Claremont McKenna College, Claremont, CA
- MD, 2000, Vanderbilt University Medical School, Nashville, TN
- PhD, 2008, University of Hawaii at Manoa
Recent and/or Significant Publications
- Nakamoto BK, Jahanshad N, McMurtray A, Kallianpur KJ, Chow DC, Valcour VG, Paul RH, Marotz L, Thompson PM, Shikuma CM. Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals. J Neurovirol. 2012 Aug;18(4):303-12. doi: 10.1007/s13365-012-0106-1. Epub 2012 May 15.
- McMurtray A, Nakamoto B, Shikuma C, Valcour V. Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study. J Stroke Cerebrovasc Dis. 2008 Jul-Aug;17(4):212-7. doi: 10.1016/j.jstrokecerebrovasdis.2008.02.005.
- McMurtray A, Nakamoto B, Shikuma C, Valcour V. Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort study. Cerebrovasc Dis. 2007;24(2-3):236-41. Epub 2007 Jun 28.